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Article

Temporal and spatial downregulation of Arabidopsis MET1 activity results in global DNA hypomethylation and developmental defects.

Molecules and cells - 31 Dec 2008

Kim Minhee, Ohr Hyonhwa, Lee Jee Woong, Hyun Youbong, Fischer Robert L, Choi Yeonhee

Abstract excerpt

DNA methylation is an epigenetic mechanism for gene silencing. In Arabidopsis, MET1 is the primary DNA methyltransferase that maintains CG DNA methylation. Plants having an overall reduction of MET1 activity, caused by a met1 mutation or a constitutively expressed MET1 antisense gene, display genome hypomethylation, inappropriate gene and transposon transcription, and developmental abnormalities. However, the...

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PMID: 18820427
PMCID: PMC4109710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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