Article
Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.
Oncogene - 7 Mar 2013
Muller P A J, Trinidad A G, Timpson P, Morton J P, Zanivan S, van den Berghe P V E, Nixon C, Karim S A, Caswell P T, Noll J E, Coffill C R, Lane D P, Sansom O J, Neilsen P M, Norman J C, Vousden K H
Abstract excerpt
Tumour-derived mutant p53 proteins promote invasion, in part, by enhancing Rab coupling protein (RCP)-dependent receptor recycling. Here we identified MET as an RCP-binding protein and showed that mutant p53 promoted MET recycling. Mutant p53-expressing cells were more sensitive to hepatocyte growth factor, the ligand for MET, leading to enhanced MET signalling, invasion and cell scattering that was dependent on...
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