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Article

Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1991

Vandenberg P, Khillan J S, Prockop D J, Helminen H, Kontusaari S, Ala-Kokko L

Abstract excerpt

A minigene version of the human gene for type II procollagen (COL2A1) was prepared that lacked a large central region containing 12 of the 52 exons and therefore 291 of the 1523 codons of the gene. The construct was modeled after sporadic in-frame deletions of collagen genes that cause synthesis of shortened pro alpha chains that associate with normal pro alpha chains and thereby cause degradation of the...

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Identifiers

PMID: 1881905
DOI: 10.1073/pnas.88.17.7640
PMCID: PMC52357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia.PMID 1881905Read ↗

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