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Article

Disruption of the developmentally-regulated Col2a1 pre-mRNA alternative splicing switch in a transgenic knock-in mouse model.

Matrix biology : journal of the International Society for Matrix Biology - 1 Apr 2012

Lewis Renate, Ravindran Soumya, Wirthlin Louisa, Traeger Geoffrey, Fernandes Russell J, McAlinden Audrey

Abstract excerpt

The present study describes the generation of a knock-in mouse model to address the role of type II procollagen (Col2a1) alternative splicing in skeletal development and maintenance. Alternative splicing of Col2a1 precursor mRNA is a developmentally-regulated event that only occurs in chondrogenic tissue. Normally, chondroprogenitor cells synthesize predominantly exon 2-containing mRNA isoforms (type IIA and IID)...

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Source

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Identifiers

PMID: 22248926
DOI: 10.1016/j.matbio.2011.12.004
PMCID: PMC3295890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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