Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STAT1/IRF‐1 signaling pathway mediates the injurious effect of interferon‐gamma on oligodendrocyte progenitor cells

15 Jul 2009

Abstract excerpt

Interferon-gamma (IFN-gamma) is a pleiotropic cytokine that is critically involved in the pathogenesis of inflammatory demyelinating diseases. There is strong evidence that IFN-gamma can function as a distinct and independent injurious factor to oligodendrocyte progenitor cells (OPCs). The intracellular signaling pathways leading to OPC death, however, remain poorly understood. In this study, we examined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Multiple Sclerosis Research Studies
Share to Reproductive System and Pregnancy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19606498
DOI: 10.1002/glia.20912

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STAT1/IRF‐1 signaling pathway mediates the injurious effect of interferon‐gamma on oligodendrocyte progenitor cellsPMID 19606498Read ↗

Cooperative contributions of Interferon regulatory factor 1 (IRF1) and IRF8 to interferon-γ-mediated cytotoxic effects on oligodendroglial progenitor cellsSemantic proximity Read ↗

Interferons, Signal Transduction Pathways, and the Central Nervous SystemSemantic proximity Read ↗

Interferon-gamma promotes differentiation of neural progenitor cells via the JNK pathway.Semantic proximity Read ↗

Protection of ZIKV infection-induced neuropathy by abrogation of acute antiviral response in human neural progenitorsSemantic proximity Read ↗

IFN-γ synergizes with TNF-α to induce RIPK1-independent necroptosis of mesenchymal stem/stromal cellsSemantic proximity Read ↗

Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma.Semantic proximity Read ↗

Type I interferons are essential mediators of apoptotic death in virally infected cellsSemantic proximity Read ↗

Stat1 is an inducible transcriptional repressor of neural stem cells self-renewal program during neuroinflammationSemantic proximity Read ↗

Retinal ganglion cell survival after severe optic nerve injury is modulated by crosstalk between JAK/STAT signaling and innate immune responses in the zebrafish retinaSemantic proximity Read ↗

Type I interferon-regulated gene expression and signaling in murine mixed glial cells lacking signal transducers and activators of transcription 1 or 2 or interferon regulatory factor 9Semantic proximity Read ↗

Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma.Semantic proximity Read ↗

EGR1 Upregulation during Encephalitic Viral Infections Contributes to Inflammation and Cell DeathSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.