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Article

Essential role for fibrillin-2 in zebrafish notochord and vascular morphogenesis.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2008

Gansner John M, Madsen Erik C, Mecham Robert P, Gitlin Jonathan D

Abstract excerpt

Recent studies demonstrate that lysyl oxidase cuproenzymes are critical for zebrafish notochord formation, but the molecular mechanisms of copper-dependent notochord morphogenesis are incompletely understood. We, therefore, conducted a forward genetic screen for zebrafish mutants that exhibit notochord sensitivity to lysyl oxidase inhibition, yielding a mutant with defects in notochord and vascular morphogenesis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18816837
DOI: 10.1002/dvdy.21705
PMCID: PMC3081706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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