Article
Essential role for the alpha 1 chain of type VIII collagen in zebrafish notochord formation.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2008
Gansner John M, Gitlin Jonathan D
Abstract excerpt
Several zebrafish mutants identified in large-scale forward genetic screens exhibit notochord distortion. We now report the cloning and further characterization of one such mutant, gulliver(m208) (gul(m208)). The notochord defect in gul(m208) mutants is exacerbated under conditions of copper depletion or lysyl oxidase cuproenzyme inhibition that are without a notochord effect on wild-type embryos. The gul(m208)...
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