Article
Juxtaposition of chemical and mutation-induced developmental defects in zebrafish reveal a copper-chelating activity for kalihinol F.
Chemistry & biology - 20 Jun 2013
Sandoval Imelda T, Manos Elizabeth J, Van Wagoner Ryan M, Delacruz Richard Glenn C, Edes Kornelia, Winge Dennis R, Ireland Chris M, Jones David A
Abstract excerpt
A major hurdle in using complex systems for drug screening is the difficulty of defining the mechanistic targets of small molecules. The zebrafish provides an excellent model system for juxtaposing developmental phenotypes with mechanism discovery using organism genetics. We carried out a phenotype-based screen of uncharacterized small molecules in zebrafish that produced a variety of chemically induced...
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