Article
Clinical significance of a set of single nucleotide polymorphisms of hepatitis B virus core gene in Chinese Han patients with chronic hepatitis B.
Journal of medical virology - 1 Nov 2008
Li Yirong, Wang Xuepin, Chen Fenghua, Ma Ronghong, Wen Xiaobo, Hu Lihua
Abstract excerpt
To evaluate clinical significance of a set of SNPs of HBV core gene, a modified PCR-RFLP assay developed by Hannoun was adapted to determine HBV SNPs in 312 Chinese Han patients with chronic hepatitis B. Five typical RFLP patterns were found and named RFLP patterns C, D, E, G, and C/G mixture. The distribution of RFLP patterns was as follows: C, 61.5%; D, 2.6%; E, 9.6%; G, 16.7%; C/G mixture, 9.6%. The PCR...
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