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Article

The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells.

The EMBO journal - 15 Nov 2001

Niedernhofer L J, Essers J, Weeda G, Beverloo B, de Wit J, Muijtjens M, Odijk H, Hoeijmakers J H, Kanaar R

Abstract excerpt

The Ercc1-Xpf heterodimer, a highly conserved structure-specific endonuclease, functions in multiple DNA repair pathways that are pivotal for maintaining genome stability, including nucleotide excision repair, interstrand crosslink repair and homologous recombination. Ercc1-Xpf incises double-stranded DNA at double-strand/single-strand junctions, making it an ideal enzyme for processing DNA structures that...

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Identifiers

PMID: 11707424
DOI: 10.1093/emboj/20.22.6540
PMCID: PMC125716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells.PMID 11707424Read ↗

Function and Interactions of ERCC1-XPF in DNA Damage ResponseSemantic proximity Read ↗

XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening.Semantic proximity Read ↗

The Structure of the Human ERCC1/XPF Interaction Domains Reveals a Complementary Role for the Two Proteins in Nucleotide Excision RepairSemantic proximity Read ↗

Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.Semantic proximity Read ↗

Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms.Semantic proximity Read ↗

The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways.Semantic proximity Read ↗

ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break RepairSemantic proximity Read ↗

ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells.Semantic proximity Read ↗

Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance.Semantic proximity Read ↗

Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease.Semantic proximity Read ↗

Activity of individual ERCC1 and XPF subunits in DNA nucleotide excision repair.Semantic proximity Read ↗

Mapping of interaction domains between human repair proteins ERCC1 and XPFSemantic proximity Read ↗

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