Activity of individual ERCC1 and XPF subunits in DNA nucleotide excision repair.

doi:10.1093/nar/29.4.872

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Article

Activity of individual ERCC1 and XPF subunits in DNA nucleotide excision repair.

Nucleic acids research - 15 Feb 2001

Gaillard Pierre-Henri L, Wood R D

Abstract excerpt

ERCC1-XPF is a structure-specific nuclease with two subunits, ERCC1 and XPF. The enzyme cuts DNA at junctions where a single strand moves 5' to 3' away from a branch point with duplex DNA. This activity has a central role in nucleotide excision repair (NER), DNA cross-link repair and recombination. To dissect the activities of the nuclease it is necessary to investigate the subunits individually, as studies of...

Topics

Amino Acid Sequence
Animals
Binding Sites
CHO Cells
Cell Extracts
Conserved Sequence
Cricetinae
DNA
DNA Repair
DNA-Binding Proteins
Dimerization
Endonucleases
Escherichia coli
Genetic Complementation Test
Humans
Molecular Sequence Data
Mutation
Precipitin Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 11160918
DOI: 10.1093/nar/29.4.872
PMCID: PMC29621

Genes

ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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