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Article

Activity of individual ERCC1 and XPF subunits in DNA nucleotide excision repair.

Nucleic acids research - 15 Feb 2001

Gaillard Pierre-Henri L, Wood R D

Abstract excerpt

ERCC1-XPF is a structure-specific nuclease with two subunits, ERCC1 and XPF. The enzyme cuts DNA at junctions where a single strand moves 5' to 3' away from a branch point with duplex DNA. This activity has a central role in nucleotide excision repair (NER), DNA cross-link repair and recombination. To dissect the activities of the nuclease it is necessary to investigate the subunits individually, as studies of...

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Identifiers

PMID: 11160918
DOI: 10.1093/nar/29.4.872
PMCID: PMC29621

Genes

ERCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Activity of individual ERCC1 and XPF subunits in DNA nucleotide excision repair.PMID 11160918Read ↗

Function and Interactions of ERCC1-XPF in DNA Damage ResponseSemantic proximity Read ↗

Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.Semantic proximity Read ↗

The Structure of the Human ERCC1/XPF Interaction Domains Reveals a Complementary Role for the Two Proteins in Nucleotide Excision RepairSemantic proximity Read ↗

Mapping of interaction domains between human repair proteins ERCC1 and XPFSemantic proximity Read ↗

The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways.Semantic proximity Read ↗

ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break RepairSemantic proximity Read ↗

Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease.Semantic proximity Read ↗

DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy.Semantic proximity Read ↗

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Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms.Semantic proximity Read ↗

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