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Article

An empirical test of the significance of an observed quantitative trait locus effect that preserves additive genetic variation.

Genetic epidemiology - 1 Jan 1999

Iturria S J, Williams J T, Almasy L, Dyer T D, Blangero J

Abstract excerpt

We propose a constrained permutation test that assesses the significance of an observed quantitative trait locus effect against a background of genetic and environmental variation. Permutations of phenotypes are not selected at random, but rather are chosen in a manner that attempts to maintain the additive genetic variability in phenotypes. Such a constraint maintains the nonindependence among observations under...

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Identifiers

PMID: 10597431
DOI: 10.1002/gepi.1370170729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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