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Article

Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia.

Psychiatry research - 30 Dec 2012

Ferrari Marco, Bolla Emilio, Bortolaso Paola, Callegari Camilla, Poloni Nicola, Lecchini Sergio, Vender Simone, Marino Franca, Cosentino Marco

Abstract excerpt

We investigated the relationships between common polymorphisms in CYP1A2 (CYP1A2(⁎)1C and (⁎)1F), CYP1A2-mRNA levels in circulating lymphocytes and clozapine(CLZ)-induced adverse drug reactions (ADRs) in 34 patients. Patients with ADRs had a higher frequency of CYP1A2 low activity allele combinations (8/12; 67%) and lower CYP1A2-mRNA levels than patients without ADRs (6/22; 27%, P=0.019).

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Identifiers

PMID: 22901441
DOI: 10.1016/j.psychres.2012.07.002

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