An In Vivo and In Vitro Model of <i>Plasmodium falciparum</i> Rosetting and Autoagglutination Mediated by <i>varO</i> , a Group A <i>var</i> Gene Encoding a Frequent Serotype

Abstract excerpt

In the Saimiri sciureus monkey, erythrocytes infected with the varO antigenic variant of the Plasmodium falciparum Palo Alto 89F5 clone bind uninfected red blood cells (rosetting), form autoagglutinates, and have a high multiplication rate, three phenotypic characteristics that are associated with severe malaria in human patients. We report here that varO parasites express a var gene having the characteristics of...

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