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Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the <i>Plasmodium falciparum</i> virulence-associated rosetting phenotype

2024-07-22

Abstract excerpt

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a diverse family of variant surface antigens, encoded by var genes, that mediates binding of infected erythrocytes to human cells and plays a key role in parasite immune evasion and malaria pathology. The increased availability of parasite genome sequence data has revolutionised the ability to study PfEMP1 diversity across multiple P. falciparum is...

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Literature Corpus work
0fdc2b48-111a-51d6-a0ec-2a267903227c
DOI
10.1101/2024.07.22.604565
Open publication

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Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the <i>Plasmodium falciparum</i> virulence-associated rosetting phenotypeDOI 10.1101/2024.07.22.604565
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