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Article

Acetylation of Rsc4p by Gcn5p is essential in the absence of histone H3 acetylation.

Molecular and cellular biology - 1 Dec 2008

Choi Jennifer K, Grimes Daniel E, Rowe Keegan M, Howe Leann J

Abstract excerpt

Rsc4p, a subunit of the RSC chromatin-remodeling complex, is acetylated at lysine 25 by Gcn5p, a well-characterized histone acetyltransferase (HAT). Mutation of lysine 25 does not result in a significant growth defect, and therefore whether this modification is important for the function of the essential RSC complex was unknown. In a search to uncover the molecular basis for the lethality resulting from loss of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18809572
DOI: 10.1128/MCB.00570-08
PMCID: PMC2593378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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