Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SDS-22 stabilizes GSP-1/-2 PP1 subunits contributing to polarity establishment in C. elegans embryos.

EMBO reports - 1 Dec 2025

Li Yi, Calvi Ida, Gotta Monica

Abstract excerpt

In many cells, polarity depends on the asymmetric distribution of the conserved PAR proteins, maintained by a balanced activity between kinases and phosphatases. The C. elegans one-cell embryo is polarized along the anterior-posterior axis, with the atypical protein kinase C PKC-3 enriched in the anterior, and the ring finger protein PAR-2 in the posterior. PAR-2 localization is regulated by PKC-3 and the PP1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins
Share to Cell Polarity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to Mutation

Share to Proteasome Endopeptidase Complex

Share to Protein Kinase C

Share to Protein Phosphatase 1

Source

Open in PubMed Open full text

Identifiers

PMID: 41198903
DOI: 10.1038/s44319-025-00624-0
PMCID: PMC12714725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SDS-22 stabilizes GSP-1/-2 PP1 subunits contributing to polarity establishment in C. elegans embryos.PMID 41198903Read ↗

SDS-22 stabilizes the PP1 catalytic subunits GSP-1/-2 contributing to polarity establishment in <i>C. elegans</i> embryosSemantic proximity Read ↗

A genome-wide RNAi screen for enhancers of par mutants reveals new contributors to early embryonic polarity in Caenorhabditis elegans.Semantic proximity Read ↗

PAR-2, LGL-1 and the CDC-42 GAP CHIN-1 act in distinct pathways to maintain polarity in the C. elegans embryo.Semantic proximity Read ↗

The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.Semantic proximity Read ↗

CDC-42 controls early cell polarity and spindle orientation in C. elegans.Semantic proximity Read ↗

Pod-2, along with pod-1, defines a new class of genes required for polarity in the early Caenorhabditis elegans embryo.Semantic proximity Read ↗

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos.Semantic proximity Read ↗

Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development.Semantic proximity Read ↗

Control of cleavage spindle orientation in Caenorhabditis elegans: the role of the genes par-2 and par-3.Semantic proximity Read ↗

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.Semantic proximity Read ↗

PAR-3 mediates the initial clustering and apical localization of junction and polarity proteins during C. elegans intestinal epithelial cell polarization.Semantic proximity Read ↗

Deubiquitylation machinery is required for embryonic polarity in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.