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Article

COMT ValMet moderation of cannabis-induced psychosis: a momentary assessment study of 'switching on' hallucinations in the flow of daily life.

Acta psychiatrica Scandinavica - 1 Feb 2009

Henquet C, Rosa A, Delespaul P, Papiol S, Fananás L, van Os J, Myin-Germeys I

Abstract excerpt

OBJECTIVE: A functional polymorphism in the catechol-o-methyltransferase gene (COMT Val(158)Met) may moderate the psychosis-inducing effects of cannabis. In order to extend this finding to dynamic effects in the flow of daily life, a momentary assessment study of psychotic symptoms in response to cannabis use was conducted. METHOD: The experience sampling technique was used to collect data on cannabis use and...

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Source

Identifiers

PMID: 18808401
DOI: 10.1111/j.1600-0447.2008.01265.x

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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COMT ValMet moderation of cannabis-induced psychosis: a momentary assessment study of 'switching on' hallucinations in the flow of daily life.PMID 18808401Read ↗

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Evidence that interactive effects of COMT and MTHFR moderate psychotic response to environmental stress.Semantic proximity Read ↗

COMT Val158Met moderation of stress-induced psychosis.Semantic proximity Read ↗

COMT Val(158)Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions.Semantic proximity Read ↗

The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta - analysis.Semantic proximity Read ↗

Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder.Semantic proximity Read ↗

Genetic moderation of the effects of cannabis: catechol-O-methyltransferase (COMT) affects the impact of Δ9-tetrahydrocannabinol (THC) on working memory performance but not on the occurrence of psychotic experiences.Semantic proximity Read ↗

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Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation.Semantic proximity Read ↗

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