Article
Genetic analysis for five LRRK2 mutations in a Sardinian parkinsonian population: importance of G2019S and R1441C mutations in sporadic Parkinson's disease patients.
Parkinsonism & related disorders - 1 May 2009
Floris Gianluca, Cannas Antonino, Solla Paolo, Murru Maria Rita, Tranquilli Stefania, Corongiu Daniela, Rolesu Marcella, Cuccu Stefania, Sardu Claudia, Marrosu Francesco, Marrosu Maria Giovanna
Abstract excerpt
Mutations in the LRRK2 gene are the most common known cause of familial and sporadic Parkinson's disease (PD). Few studies performed to date to assess frequency of these mutations are actually only representative of specific areas. Here we study the frequency and clinical phenotype of LRRK2 G2019S, I2020T and R1441C/G/H mutations in 356 Sardinian patients with idiopathic PD and 208 controls. Seventeen additional...
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