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Article

Combined effects of MDM2 SNP 309 and p53 mutation on oral squamous cell carcinomas associated with areca quid chewing.

Oral oncology - 1 Jan 2009

Huang Shiang-Fu, Chen I-How, Liao Chun-Ta, Wang Hung-Ming, Liou Saou-Hsing, Hsieh Ling-Ling

Abstract excerpt

The recently identified single nucleotide polymorphism in the MDM2 promoter (SNP 309) may contribute to the early onset of both sporadic and hereditary malignancies in patients with defective p53. We tested this hypothesis by examining the effects of combined MDM2 polymorphisms and somatic p53 mutations on 351 oral squamous cell carcinomas (OSCCs) associated with areca quid chewing. We found that the G allele of...

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Source

Identifiers

PMID: 18487080
DOI: 10.1016/j.oraloncology.2008.03.006

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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