Article
Association of MDM2 SNP309, age of onset, and gender in cutaneous melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2009
Firoz Elnaz F, Warycha Melanie, Zakrzewski Jan, Pollens Danuta, Wang Guimin, Shapiro Richard, Berman Russell, Pavlick Anna, Manga Prashiela, Ostrer Harry, Celebi Julide Tok, Kamino Hideko, Darvishian Farbod, Rolnitzky Linda, Goldberg Judith D, Osman Iman, Polsky David
Abstract excerpt
PURPOSE: In certain cancers, MDM2 SNP309 has been associated with early tumor onset in women. In melanoma, incidence rates are higher in women than in men among individuals less than 40 years of age, but among those older than 50 years of age, melanoma is more frequent in men than in women. To investigate this difference, we examined the association among MDM2 SNP309, age at diagnosis, and gender among melanoma...
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