Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder.

Journal of affective disorders - 1 Apr 2009

Roecklein Kathryn A, Rohan Kelly J, Duncan Wallace C, Rollag Mark D, Rosenthal Norman E, Lipsky Robert H, Provencio Ignacio

Abstract excerpt

BACKGROUND: Melanopsin, a non-visual photopigment, may play a role in aberrant responses to low winter light levels in Seasonal Affective Disorder (SAD). We hypothesize that functional sequence variation in the melanopsin gene could contribute to increasing the light needed for normal functioning...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Rod Opsins
Share to Polymorphism, Single Nucleotide
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Homozygote

Share to Logistic Models

Share to Mutation, Missense

Share to Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 18804284
DOI: 10.1016/j.jad.2008.08.005
PMCID: PMC2647333

Genes

OPN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18804284-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder.PMID 18804284Read ↗

The post illumination pupil response is reduced in seasonal affective disorder.Semantic proximity Read ↗

Melanopsin gene variations interact with season to predict sleep onset and chronotype.Semantic proximity Read ↗

Defining the impact of melanopsin missense polymorphisms using in vivo functional rescue.Semantic proximity Read ↗

Functional characterisation of naturally occurring mutations in human melanopsin.Semantic proximity Read ↗

Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference.Semantic proximity Read ↗

Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression.Semantic proximity Read ↗

Seasonal affective disorder and the G-protein beta-3-subunit C825T polymorphism.Semantic proximity Read ↗

Impact of Human Melanopsin Gene (OPN4) Polymorphisms (I394T, P10L) on Nocturnal Melatonin and Daily Rhythms in Young Adults.Semantic proximity Read ↗

C825T polymorphism in the G protein beta3-subunit gene is associated with seasonal affective disorder.Semantic proximity Read ↗

Association of CLOCK, ARNTL, and NPAS2 gene polymorphisms and seasonal variations in mood and behavior.Semantic proximity Read ↗

Seasonality and winter-type seasonal depression are associated with the rs731779 polymorphism of the serotonin-2A receptor gene.Semantic proximity Read ↗

Summer and SERT: Effect of daily sunshine hours on<i>SLC6A4</i>promoter methylation in seasonal affective disorderSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.