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Article

Functional characterisation of naturally occurring mutations in human melanopsin.

Cellular and molecular life sciences : CMLS - 1 Oct 2018

Rodgers Jessica, Peirson Stuart N, Hughes Steven, Hankins Mark W

Abstract excerpt

Melanopsin is a blue light-sensitive opsin photopigment involved in a range of non-image forming behaviours, including circadian photoentrainment and the pupil light response. Many naturally occurring genetic variants exist within the human melanopsin gene (OPN4), yet it remains unclear how these variants affect melanopsin protein function and downstream physiological responses to light. Here, we have used...

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Source

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Identifiers

PMID: 29700553
DOI: 10.1007/s00018-018-2813-0
PMCID: PMC6133154

Genes

OPN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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