Seasonality and winter-type seasonal depression are associated with the rs731779 polymorphism of the serotonin-2A receptor gene.

doi:10.1016/j.euroneuro.2010.04.009

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Article

Seasonality and winter-type seasonal depression are associated with the rs731779 polymorphism of the serotonin-2A receptor gene.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Sept 2010

Molnar Eszter, Lazary Judit, Benko Anita, Gonda Xenia, Pap Dorottya, Mekli Krisztina, Juhasz Gabriella, Kovacs Gabor, Kurimay Tamas, Rihmer Zoltan, Bagdy Gyorgy

Abstract excerpt

Seasonal Affective Disorder (SAD), seasonality and increased sensitivity to the fluctuation of seasons in biological and psychological parameters can manifest to varying degrees across a normal population. The serotonin-2A (5-HT2A) receptor gene has long been suggested as a candidate for the genetic basis of this phenomenon. We hypothesized that functional sequence variation in this gene could contribute to...

Topics

Adolescent
Adult
Female
Genetic Association Studies
Genotype
Haplotypes
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Psychiatric Status Rating Scales

Receptor, Serotonin, 5-HT2A

Seasonal Affective Disorder

Seasons

Young Adult

Source

Open in PubMed

Identifiers

PMID: 20580209
DOI: 10.1016/j.euroneuro.2010.04.009

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