Article
Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression.
Annals of medicine - 1 Jan 2007
Partonen Timo, Treutlein Jens, Alpman Asude, Frank Josef, Johansson Carolina, Depner Martin, Aron Liviu, Rietschel Marcella, Wellek Stefan, Soronen Pia, Paunio Tiina, Koch Andreas, Chen Ping, Lathrop Mark, Adolfsson Rolf, Persson Maj-Liz, Kasper Siegfried, Schalling Martin, Peltonen Leena, Schumann Gunter
Abstract excerpt
BACKGROUND: Multiple lines of evidence suggest that the circadian clock contributes to the pathogenesis of winter depression or seasonal affective disorder (SAD). We hypothesized that sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at the core of the circadian clock, predispose to winter depression. METHODS: In silico analysis of the biological effects of allelic...
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