Article
Melanopsin gene variations interact with season to predict sleep onset and chronotype.
Chronobiology international - 1 Oct 2012
Roecklein Kathryn A, Wong Patricia M, Franzen Peter L, Hasler Brant P, Wood-Vasey W Michael, Nimgaonkar Vishwajit L, Miller Megan A, Kepreos Kyle M, Ferrell Robert E, Manuck Stephen B
Abstract excerpt
The human melanopsin gene has been reported to mediate risk for seasonal affective disorder (SAD), which is hypothesized to be caused by decreased photic input during winter when light levels fall below threshold, resulting in differences in circadian phase and/or sleep. However, it is unclear if melanopsin increases risk of SAD by causing differences in sleep or circadian phase, or if those differences are...
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