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Article

Evaluation of genetic association and expression reduction of TRPC1 in the development of diabetic nephropathy.

American journal of nephrology - 1 Jan 2009

Zhang Dongying, Freedman Barry I, Flekac Milan, Santos Elisabete, Hicks Pamela J, Bowden Donald W, Efendic Suad, Brismar Kerstin, Gu Harvest F

Abstract excerpt

BACKGROUND/AIMS: The TRPC1 gene on chromosome 3q22-24 resides within the linkage region for diabetic nephropathy (DN) in type 1 (T1D) and type 2 diabetes mellitus (T2D). A recent study has demonstrated that TRPC1 expression is reduced in the kidney of diabetic ZDF- and STZ-treated rats. The present study aimed to evaluate the genetic and functional role of TRPC1 in the development of DN. METHODS: Genetic...

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Source

Open in PubMed Open full text

Identifiers

PMID: 18802326
DOI: 10.1159/000157627
PMCID: PMC2698220

Genes

TRPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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