Article
TRPC6 single nucleotide polymorphisms and progression of idiopathic membranous nephropathy.
PloS one - 1 Jan 2014
Hofstra Julia M, Coenen Marieke J H, Schijvenaars Mascha M V A P, Berden Jo H M, van der Vlag Johan, Hoefsloot Lies H, Knoers Nine V A M, Wetzels Jack F M, Nijenhuis Tom
Abstract excerpt
BACKGROUND: Activating mutations in the Transient Receptor Potential channel C6 (TRPC6) cause autosomal dominant focal segmental glomerular sclerosis (FSGS). TRPC6 expression is upregulated in renal biopsies of patients with idiopathic membranous glomerulopathy (iMN) and animal models thereof. In iMN, disease progression is characterized by glomerulosclerosis. In addition, a context-dependent TRPC6 overexpression...
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