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Article

An Inducible hiPSC-Derived Human Podocyte Model for Functional Analysis of TRPC6 Variants Associated with FSGS.

Cells - 17 Apr 2026

Batool Lilas, Hariharan Krithika, Stölting Gabriel, Zhong Tingting, Tsvetkov Dimitry, Gossen Manfred, Kurtz Andreas

Abstract excerpt

Podocyte injury is a characteristic feature of focal segmental glomerulosclerosis (FSGS) that leads to the development of nephrosis as its loss causes proteinuria and progressive glomerulosclerosis. The physiological function of podocytes is critically dependent on proper intracellular calcium levels; an excess or shortage of calcium influx in these cells may result in foot process effacement, apoptosis, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glomerulosclerosis, Focal Segmental

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Source

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Identifiers

PMID: 42041578
DOI: 10.3390/cells15080712
PMCID: PMC13115377

Genes

TRPC6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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An Inducible hiPSC-Derived Human Podocyte Model for Functional Analysis of TRPC6 Variants Associated with FSGS.PMID 42041578Read ↗

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