Article
Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase.
Science (New York, N.Y.) - 18 Aug 2000
Belaaouaj A, Kim K S, Shapiro S D
Abstract excerpt
In determining the mechanism of neutrophil elastase (NE)-mediated killing of Escherichia coli, we found that NE degraded outer membrane protein A (OmpA), localized on the surface of Gram-negative bacteria. NE killed wild-type, but not OmpA-deficient, E. coli. Also, whereas NE-deficient mice had impaired survival in response to E. coli sepsis, as compared to wild-type mice, the presence or absence of NE had no...
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