Article
Evidence for a functional RNA element in the hepatitis C virus core gene.
Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2007
McMullan Laura K, Grakoui Arash, Evans Matthew J, Mihalik Kathleen, Puig Montserrat, Branch Andrea D, Feinstone Stephen M, Rice Charles M
Abstract excerpt
In the core protein-coding region of hepatitis C virus (HCV), evidence exists for both phylogenetically conserved RNA structures and a +1 alternative reading frame (ARF). To investigate its role in HCV infection, we introduced four stop codons into the ARF of a genotype 1a H77 molecular clone. The changes did not alter the core protein sequence, but were predicted to disrupt RNA secondary structures. An...
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