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Article

Open Reading Frame 4 Is Not Essential in the Replication and Infection of Genotype 1 Hepatitis E Virus.

Viruses - 18 Mar 2023

Bai Huimin, Ami Yasushi, Suzaki Yuriko, Doan Yen Hai, Muramatsu Masamichi, Li Tian-Cheng

Abstract excerpt

Genotype 1 hepatitis E virus (HEV-1), unlike other genotypes of HEV, has a unique small open reading frame known as ORF4 whose function is not yet known. ORF4 is located in an out-framed manner in the middle of ORF1, which encodes putative 90 to 158 amino acids depending on the strains. To explore the role of ORF4 in HEV-1 replication and infection, we cloned the complete genome of wild-type HEV-1 downstream of a...

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Identifiers

PMID: 36992492
DOI: 10.3390/v15030784
PMCID: PMC10052008

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