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Article

Senp1 is essential for desumoylating Sumo1-modified proteins but dispensable for Sumo2 and Sumo3 deconjugation in the mouse embryo.

Cell reports - 30 May 2013

Sharma Prashant, Yamada Satoru, Lualdi Margaret, Dasso Mary, Kuehn Michael R

Abstract excerpt

Posttranslational modification with small ubiquitin-like modifier (Sumo) regulates numerous cellular and developmental processes. Sumoylation is dynamic with deconjugation by Sumo-specific proteases (Senps) regulating steady-state levels. Different Senps are found in distinct subcellular domains, which may limit their deconjugation activity to colocalizing Sumo-modified proteins. In vitro, Senps can discriminate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23684609
DOI: 10.1016/j.celrep.2013.04.016
PMCID: PMC3775507

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