Article
Hypothalamic-pituitary-adrenal axis disregulation in PrPC-null mice.
Neuroreport - 8 Oct 2008
Sanchez-Alavez Manuel, Criado José R, Klein Izabella, Moroncini Gianluca, Conti Bruno
Abstract excerpt
As manifestations of prion diseases include disturbances of hypothalamic and pituitary functions, we tested the hypothesis that the cellular prion protein (PrPC) has a role as modulator of the hypothalamic-pituitary-adrenal axis. The level of corticosterone and adrenocorticotropic hormone were compared in PrPC null (PrP 0/0) and wild-type (PrP+/+) mice. PrP 0/0 showed hypercorticism during the dark part of day....
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