Article
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents.
Bioorganic & medicinal chemistry letters - 15 Oct 2008
Dragovich Peter S, Blazel Julie K, Ellis David A, Han Qing, Kamran Ruhi, Kissinger Charles R, LeBrun Laurie A, Li Lian-Sheng, Murphy Douglas E, Noble Michael, Patel Rupal A, Ruebsam Frank, Sergeeva Maria V, Shah Amit M, Showalter Richard E, Tran Chinh V, Tsan Mei, Webber Stephen E, Kirkovsky Leo, Zhou Yuefen
Abstract excerpt
The synthesis of 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones bearing 6-amino substituents as potent inhibitors of the HCV RNA-dependent RNA polymerase (NS5B) is described. Several of these agents also display potent antiviral activity in...
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