Article
Synthesis and SAR of novel 1,1-dialkyl-2(1H)-naphthalenones as potent HCV polymerase inhibitors.
Bioorganic & medicinal chemistry letters - 15 Jan 2008
Bosse Todd D, Larson Daniel P, Wagner Rolf, Hutchinson Doug K, Rockway Todd W, Kati Warren M, Liu Yaya, Masse Sherie, Middleton Tim, Mo Hongmei, Montgomery Debra, Jiang Wen, Koev Gennadiy, Kempf Dale J, Molla Akhter
Abstract excerpt
A series of gem-dialkyl naphthalenone derivatives with varied alkyl substitutions were synthesized and evaluated according to their structure-activity relationship. This investigation led to the discovery of potent inhibitors of the hepatitis C virus at low nanomolar concentrations in both enzymatic and cell-based HCV genotype 1a assays.
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