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Article

Constitutive Activation of the RON Gene Promotes Invasive Growth but Not Transformation

1 Dec 1996

Abstract excerpt

MET, RON, and SEA are members of a gene family encoding tyrosine kinase receptors with distinctive properties. Besides mediating growth, they control cell dissociation, motility ("scattering"), and formation of branching tubules. While there are transforming counterparts of MET and SEA, no oncogenic forms of RON have yet been identified. A chimeric Tpr-Ron, mimicking the oncogenic form of Met (Tpr-Met) was...

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PMID: 8943362
DOI: 10.1128/mcb.16.12.7072

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Constitutive Activation of the RON Gene Promotes Invasive Growth but Not TransformationPMID 8943362Read ↗

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A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype.Semantic proximity Read ↗

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The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasivenessSemantic proximity Read ↗

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