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Article

Impact of ACE2 genetic variant on antidepressant efficacy of SSRIs

4 Oct 2021

Abstract excerpt

Identification of a new axis of angiotensin-converting enzyme 2 (ACE2)/angiotensin (1-7)/Mas receptor, in the renin-angiotensin system (RAS), has opened a new insight regarding the role of RAS and angiotensin in higher brain functions. ACE2 catabolizes angiotensin II and produces angiotensin (1-7), an agonist of Mas receptor. Mice lacking the Mas receptor (angiotensin 1-7 receptor) exhibit anxiety-like...

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Share to Hormonal Regulation and Hypertension
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PMID: 34602110
DOI: 10.1017/neu.2021.32

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