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Article

Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation.

Science (New York, N.Y.) - 15 Mar 1996

Lanker S, Valdivieso M H, Wittenberg C

Abstract excerpt

Cyclins regulate the major cell cycle transitions in eukaryotes through association with cyclin-dependent protein kinases (CDKs). In yeast, G1 cyclins are essential, rate-limiting activators of cell cycle initiation. G1-specific accumulation of one G1 cyclin, Cln2, results from periodic gene expression coupled with rapid protein turnover. Site-directed mutagenesis of CLN2 revealed that its phosphorylation...

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PMID: 8599119
DOI: 10.1126/science.271.5255.1597

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Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation.PMID 8599119Read ↗

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