Article
Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response.
Proceedings of the National Academy of Sciences of the United States of America - 23 Oct 2001
Carroll A S, Bishop A C, DeRisi J L, Shokat K M, O'Shea E K
Abstract excerpt
In addition to its well-established role in responding to phosphate starvation, the cyclin-dependent kinase Pho85 has been implicated in a number of other physiological responses of the budding yeast Saccharomyces cerevisiae, including synthesis of glycogen. To comprehensively characterize the range of Pho85-dependent gene expression, we used a chemical genetic approach that enabled us to control Pho85 kinase...
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