Article
The human ERG1 channel polymorphism, K897T, creates a phosphorylation site that inhibits channel activity.
Proceedings of the National Academy of Sciences of the United States of America - 23 Sept 2008
Gentile Saverio, Martin Negin, Scappini Erica, Williams Jason, Erxleben Christian, Armstrong David L
Abstract excerpt
Single-nucleotide polymorphisms (SNPs) in the human ether-a-go-go-related gene 1, hERG1, are associated with cardiac arrhythmias. The Kv11.1 channels encoded by hERG1 are also essential for rhythmic excitability of the pituitary, where they are regulated by thyroid hormone through a signal transduction cascade involving the phosphatidylinositol 3-kinase (PI3K) and the Ser/Thr-directed protein phosphatase, PP5....
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