Identification of a neutralization epitope in the VP1 capsid protein of SV40.

Abstract excerpt

Three SV40 escape mutants were identified by selection in the presence of monoclonal antibodies with neutralizing activity. The VP1 amino acid alterations in these mutants were: (1) K73-->E (in loop BC); (2) D77-->E (in loop BC); (3) K171-->R (in loop EF); and (4) Q175-->H (in loop EF). These residues are clustered in close proximity to each other on the surface of the native capsid protein, strongly suggesting...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antibodies, Viral
• Share to Capsid Proteins
• Share to Cell Line