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Article

Rapid progression to simian AIDS can be accompanied by selection of CD4-independent gp120 variants with impaired ability to bind CD4.

Journal of virology - 1 Aug 2002

Ryzhova Elena, Whitbeck J Charles, Canziani Gabriela, Westmoreland Susan V, Cohen Gary H, Eisenberg Roselyn J, Lackner Andrew, González-Scarano Francisco

Abstract excerpt

Aspartate 368 on human immunodeficiency virus type 1 (HIV-1) gp120 forms multiple contacts with CD4; in mutagenesis studies, its replacement by asparagine and corresponding changes in simian immunodeficiency virus SIVmac (D385N) reduced binding with CD4. Nevertheless, simian immunodeficiency virus envelopes with D385N were prevalent in several studies. Extending these observations, we also found D385N to be...

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Source

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Identifiers

PMID: 12097605
DOI: 10.1128/jvi.76.15.7903-7909.2002
PMCID: PMC136356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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