Article
A structure-guided mutation in the major capsid protein retargets BK polyomavirus.
PLoS pathogens - 1 Jan 2013
Neu Ursula, Allen Stacy-Ann A, Blaum Bärbel S, Liu Yan, Frank Martin, Palma Angelina S, Ströh Luisa J, Feizi Ten, Peters Thomas, Atwood Walter J, Stehle Thilo
Abstract excerpt
Viruses within a family often vary in their cellular tropism and pathogenicity. In many cases, these variations are due to viruses switching their specificity from one cell surface receptor to another. The structural requirements that underlie such receptor switching are not well understood especially for carbohydrate-binding viruses, as methods capable of structure-specificity studies are only relatively...
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