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Article

Functional copy-number alterations in cancer.

PloS one - 11 Sept 2008

Taylor Barry S, Barretina Jordi, Socci Nicholas D, Decarolis Penelope, Ladanyi Marc, Meyerson Matthew, Singer Samuel, Sander Chris

Abstract excerpt

Understanding the molecular basis of cancer requires characterization of its genetic defects. DNA microarray technologies can provide detailed raw data about chromosomal aberrations in tumor samples. Computational analysis is needed (1) to deduce from raw array data actual amplification or deletion events for chromosomal fragments and (2) to distinguish causal chromosomal alterations from functionally neutral...

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Identifiers

PMID: 18784837
DOI: 10.1371/journal.pone.0003179
PMCID: PMC2527508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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