Article
High-resolution genome-wide copy-number analyses identify localized copy-number alterations in Ewing sarcoma.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Jun 2013
Lynn Miriam, Wang Yuexiang, Slater Jaime, Shah Naisha, Conroy Judith, Ennis Sean, Morris Thomas, Betts David R, Fletcher Jonathan A, O'Sullivan Maureen J
Abstract excerpt
Ewing sarcoma family tumors are aggressive sarcomas of childhood and adolescence with continuing poor outcomes. Decades of research on the characteristics of the often solitary-known oncogenic-genomic aberration in Ewing sarcoma family tumors, namely a TET-ETS fusion, have provided little advancement in the understanding of the molecular pathogenesis of Ewing sarcoma or treatment thereof. In this study, the...
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