Article
A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers.
AIDS (London, England) - 1 Oct 2008
Hardie Rae-Anne, Knight Erin, Bruneau Brigitte, Semeniuk Christina, Gill Kulvinder, Nagelkerke Nico, Kimani Joshua, Wachihi Charles, Ngugi Elizabeth, Luo Ma, Plummer Francis A
Abstract excerpt
Human leucocyte antigen-DP presents peptides to CD4 T cells and plays an important role in parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was...
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