Article
An integrative bioinformatic approach for studying escape mutations in human immunodeficiency virus type 1 gag in the Pumwani Sex Worker Cohort.
Journal of virology - 1 Feb 2008
Peters Harold O, Mendoza Mark G, Capina Rupert E, Luo Ma, Mao Xiaojuan, Gubbins Michael, Nagelkerke Nico J D, Macarthur Ian, Sheardown Brent B, Kimani Joshua, Wachihi Charles, Thavaneswaran Subo, Plummer Francis A
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) is able to evade the host cytotoxic T-lymphocyte (CTL) response through a variety of escape avenues. Epitopes that are presented to CTLs are first processed in the presenting cell in several steps, including proteasomal cleavage, transport to the endopl...
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