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Article

Pharmacogenetic relevance of MTHFR polymorphisms.

Pharmacogenomics - 1 Sept 2008

Toffoli Giuseppe, De Mattia Elena

Abstract excerpt

The 5,10-methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for intracellular folate homeostasis and metabolism. Two common MTHFR polymorphisms, C677T and A1298C, which lead to an altered amino acid sequence, have been associated with a decreased enzyme activity and susceptibility to cancer suggesting that these genetic variants may modulate the risk of several malignancies. C667T, and to a lesser extent...

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Source

Identifiers

PMID: 18781847
DOI: 10.2217/14622416.9.9.1195

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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