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Generation of <i>Cyp17</i>iCre transgenic mice and their application to conditionally delete estrogen receptor alpha (<i>Esr1</i>) from the ovary and testis

1 Sept 2008

Abstract excerpt

A transgenic mouse line that expresses iCre under regulation of the Cytochrome P(450) 17alpha-hydroxylase/17, 20-lyase (Cyp17) promoter was developed as a novel transgenic mouse model for the conditional deletion of genes specifically in the theca/interstitial cells of the ovary and Leydig cells of the testis. In this report, we describe the development of Cyp17iCre mice and the application of these mice for...

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PMID: 18781648
DOI: 10.1002/dvg.20428

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